DBCO Amine (CCT-A103)

Description

DBCO Amine is a simple DBCO-containing building block used to derivatize carboxyl groups in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) with DBCO moiety through a stable amide bond.

DBCO reagents, also know as ADIBO or DIBAC are the most commonly used substrates for copper-free click reaction. DBCO compounds react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

Specifications

Documents

Selected References

1. Davis, G. J., et al. (2021). Copper-Free Click Enabled Triazabutadiene for Bioorthogonal Protein Functionalization. Bioconjugate Chem., 32 (2), 254-258. [PubMed]
2. Kakwere, K., et al. (2018). Unimicellar hyperstars as multi-antigen cancer nanovaccines displaying clustered epitopes of immunostimulating peptides. Biomater. Sci., 6, 5850-8. [PubMed]
3. Zeng D., et al. (2012). ⁶⁴Cu Core-labeled Nanoparticles with High Specific Activity via Metal-Free Click Chemistry. ACS Med Chem Lett., 6(6), 5209–19. [PubMed]
4. Bouvet, V., et al. (2011). Copper-free click chemistry with the short-lived positron emitter fluorine-18. Org Biomol Chem., 9(21), 7393-9. [PubMed]
5. Carpenter, R.D., et al. (2011). Copper-Free Click for PET: Rapid 1,3-Dipolar Cycloadditions with a Fluorine-18 Cyclooctyne. ACS Med Chem Lett., 2(12), 885-9. [PubMed]
6. Arumugam S., et al. (2011). [18F]azadibenzocyclooctyne ([18F]ADIBO): a biocompatible radioactive labeling synthon for peptides using catalyst free [3+2] cycloaddition. Bioorg Med Chem Lett., 21(23), 6987-91. [PubMed]