Lectins are essential in recognizing abnormal cell glycome and mediating tumor progression. That said, they can also be leveraged to enhance our knowledge of the glycome profiles of various cancers.
Why does glycobiology—the study of sugar chains—matter so much to our health? From the simplest to the most branched, carbohydrates are the key players in cellular functions—both healthy and pathological. This article summarizes the key elements of glycobiology in a nutshell.
Glycosylation networks have massive biomarker potential for breast cancer diagnosis and treatment. This study explores yet another alteration in breast cancer glycan profile: bisecting GlcNAc.
The study closely examined the glycan structures and glycoprotein expression in muscle-invasive bladder cancer, leading to the discovery of a novel biomarker: HOMER3. This article elaborates on preliminary results about the role of HOMER3 in bladder cancer metastasis.
Since it was first described in 1906 by Alois Alzheimer, physicians and scientists have been searching for clues to the debilitating neurological condition Alzheimer’s disease (AD). To diagnose and treat the disease at its earliest stages, researchers are searching for additional biomarkers that can help guide our understanding of the disease.
This study explores how the sickle cell trait could help millions of people in Sub-Saharan Africa, a high-risk malaria zone, develop resistance against malaria.
Hypersialylation of glycans is one of the key drivers in cell differentiation in cancer, including pancreatic ductal adenocarcinoma (PDAC) cells. In this article, we review a study investigating how this mechanism led to the differentiation of tumor monocytes into malignant tumor macrophages associated with low survival rates in patients.
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