AZDye 488 TCO (CCT-1356)

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Description
Specifications
Abs/Em Spectra
Documents

Description

AZDye™ 488 TCO reacts with tetrazines to produce a stable, covalent linkage, also referred to as the inverse-electron demand Diels-Alder cycloaddition reaction. This reaction is extremely fast (k > 800 M -1 s-1), selective, biocompatible, and does not require Cu-catalyst or elevated temperatures. Such excellent reaction rate constants are unparalleled by any other bioorthogonal reaction pair described to date.

AZDye™ 488 is a bright, and highly photostable, green-fluorescent probe optimally excited by the 488 nm laser line. This probe is water-soluble and its fluorescence is pH independent over a wide pH range. The brightness and photostability of blue dyes are best suited to direct imaging of low-abundance targets.

AZDye™ 488 is structurally identical to Alexa Fluor® 488. Its absorption/emission spectra is a perfect match to spectra of many other fluorescent dyes based on sulfonated rhodamine 110 core, including DyLight® 488, Alexa Fluor® 488.

DyLight® and Alexa Fluor® are a registered trademark of Thermo Fisher Scientific. Click Chemistry Tools is not affiliated with or endorsed by Thermo Fisher Scientific. AZDye™ 488 is NOT manufactured, distributed, or affiliated in any way with Thermo Fisher Scientific.

Specifications

Unit Size	1 mg, 5 mg, 25 mg
Extinction Coefficient	73,000
Spectrally Similar Dyes	Alexa Fluor® 488, Atto™ 488, CF® 488 Dye, DyLight® 488, FITC
Molecular weight	770.82
CAS	N/A
Solubility	Water, DMSO, DMF, MeOH
Purity	>95% (HPLC)
Appearance	Orange solid
Storage Conditions	-20°C. Desiccate
Shipping Conditions	Ambient temperature